ASNS and neoplasm: ASNS gene expression is observed to be reduced in some acute lymphoblastic leukemia subtypes [308] but overexpressed in other tumor types such as NSCLC, colorectal cancer CRC, and breast cancer [309,310,311], promoting tumor growth and metastasis via mTORC1 activation, enhanced stress response, epithelial–mesenchymal transition, and cell cycle progression, etc. [309,310,311].