GPI and autoimmune polyendocrinopathy: According to the current recommendations of the Scientific and Standardization Committee of the International Society on Thrombosis and Hemostasis (ISTH) from 2020 [42] and 2025 [43], the diagnosis of APS consists of determining the titer of aCL in the IgG and IgM classes, aβ2-GPI in the IgG and IgM classes, and detecting LA.