SHBG and type 2 diabetes mellitus: Perry et al. [34] conducted a meta-analysis in which carriers of the minor allele (A) of SNP rs1799941, which is just upstream of the proximal promoter of the SHBG gene and has been associated with SHBG levels in older men [35], was linked with elevated levels of SHBG and a lower risk of T2DM although other studies did not confirm this association [36].