CXCL8 and eye neoplasm: Other shared biological pathways linking CVD and OC include hypoxia and inflammation, where cytokines and factors like hypoxia inducible factor 1 alpha, interleukin 6, Interleukin 8, and monocyte chemotactic protein 1 have been implicated in the prognosis and progression of both ocular tumors and CVD [33,37].