For instance, in a study of 379 head-and-neck squamous cell carcinoma (HNSCC) cases, high density of CD8+CD103+ TRM cells in the primary tumors predicted better overall and disease-free survival, while TRM cell density in matched lymph node metastases failed to correlate with outcome, underscoring that TRM cell impact could vary by tumor site and stage [65]. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.