IQGAP1 and colorectal carcinoma: On the other hand, changes in subcellular localization of this scaffold protein have been previously described in tumoral cells; Rotoli et al. [64] showed an altered expression of IQGAP1 in colorectal carcinoma cells in comparison to healthy samples in which increased levels of IQGAP1 were found around plasma membranes, probably related to modifications in cell polarity in line with tumoral progression [65,66].