E2F1 and neoplasm: * MED12-dependent, with higher expression in MED12 mutant fibroids when compared to wild-type * Luciferase assays shows miR-29 as a target * Inhibition resulted in downregulation of COL1A1, COL3A1, TGFB3 * Knockdown in fibroid xenografts resulted in reduction of tumor weight, cell proliferation, expression of cell cycle regulatory genes (CCND1, CDK2, E2F1) and increased expression of the miR-29 family * Knockdown reduced mRNA/protein expression of COL3A1, FN1, TGFB3 and total collagen protein.