COL3A1 and neoplasm: Furthermore, in an in vivo study using human-derived fibroid xenografts implanted in SCID mice, MIAT knockdown via lentiviral delivery resulted in a 30% reduction in tumor weight [148], upregulation of miR-29 family expression, and downregulation of miR-29’s targets, including TGF-β3, FN1 (fibronectin), and COL3A1 [148], in the xenografts.