SDHD and hepatocellular carcinoma: In fact, genes that regulate fibrosis and HCC were also significantly downregulated in the KPA-treated livers (Figure 3A); these include as calcium-binding protein A10 (S100a10) [28], succinate dehydrogenase subunit (Sdhd) [29] and peroxisome-localized enzyme Idi1 [30] (Figure 3A).