CCL2 and neoplasm: Additionally, cytokine array analysis of 3D fibroblast monocultures revealed high levels of interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, IL-8, and tissue inhibitor of metalloproteinases (TIMP)-2 along with evidence suggesting small extracellular vesicles (sEVs) derived from fibroblasts may further promote the growth and invasiveness of tumor cells in 3D pNF1 cultures [22].