KRT19 and pancreatic serous cystadenoma: Additionally, analysis of circulating EVs in PSC patients has shown elevated levels of IL-13 receptor alpha 1 (IL-13Ra1), microRNA-4645-3p, and cytokeratin-19 (CK-19), which are linked to disease progression and hepatic fibrosis, suggesting their potential as non-invasive biomarkers for disease monitoring [51].