In light of the above, this study aimed to assess the expression of selected TLRs (TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9) on subpopulations of T lymphocytes (CD4+ and CD8+) and B lymphocytes (CD19+) in the peripheral blood of patients with newly diagnosed, untreated endometriosis. The gene discussed is CD4; the disease is endometriosis.