Additionally, they were able to identify different confirmations (strains) of synuclein seeds in different syuncleinopathies—paired filaments or multiple bundled filaments in serum from patients with PD and DLB, and twisted filaments and straight filaments in serum from MSA patients [61].While promising, these results need to be replicated in independent cohorts and in other laboratories. Here, SNCA is linked to multiple system atrophy.