Both H2A.Z.1 and H2A.Z.2 are credited with pro-oncogenic roles in CC, mainly through assisting the recruiting of TFs in the promoters of genes associated with cancer progression and specifically cell proliferation like NRF1, Nuclear transcription factor Y subunit alpha (NFYA), and RNA Polymerase II (RNA Pol II) [248]. This evidence concerns the gene NFYA and cancer.