The extensive literature research presented in this study revealed that ELK1 is a key transcription factor implicated in several cancer hallmarks, including the sustaining of cell proliferation signaling, the evasion of apoptosis and other cytostatic mechanisms, the activation of invasion and metastasis pathways, the epigenetic reprograming of the cancer cells, the dysregulation of the metabolism, the promotion of angiogenesis, and the remodeling of the tumor microenvironment (Figure 8). This evidence concerns the gene ELK1 and cancer.