The authors report that ELK1 is not the TF activating SSPs; however, Forkhead box C1 (FOXC1), which is a target of ELK1-mediated transcription is the responsible TF, and suggest that targeting the ELK1-FOXC1 axis could be another potential approach against 5-FU-resistant CRC tumors [135]. This evidence concerns the gene TF and colorectal carcinoma.