ELK1 was reported to be the most significant among a set of TFs (SNAI2, RUNX1, Interferon regulatory factor 1 (IRF1), HIF-1A, Activating transcription factor 2 (ATF2 or CREB2), ABL proto-oncogene 1 (ABL1), ELK1, and GATA binding protein 1 (GATA1)), since its interaction with JNK1 was suggested as a significant marker in CRC tumorigenesis and progression [122]. The gene discussed is ELK1; the disease is colorectal carcinoma.