Transcript-level analyses revealed a consistent upregulation of key glycolytic enzymes—including GLUT1, PKM, HK1, HK2, and GSK3A—in both proliferating HepaFH3 cells and HCLs (HepG2, Huh7), compared to non-HCC-PHHs. The gene discussed is GSK3A; the disease is hepatocellular carcinoma.