IRF1 and leukemia: Deletions or rearrangements of the IRF-1 tumor suppressor gene and exon skipping of the IRF-1 full-length wild type (IRF-1 WT) transcript have been described in patients with myelodysplastic syndromes (MDS) and leukemia [21,22,23,24,25,26,27,28,29,30,31].