IRF1 and rheumatoid arthritis: Many of the pathways regulated by the TMEM230/RNASET2/SDC2/IRF1 in CXCL12 fibroblast cells from RA patients including oxidative phosphorylation, MYC target genes, DNA repair, TP53, and metabolism (adipogenesis, glycolysis, and fatty acid synthesis and breakdown) (Table 2 and Table 3) were also identified in the FB2 fibroblast cell cluster from HER2+ breast cancer patients.