Stress responses associated with the ER are well represented in the pathways identified in RA and HER2+ breast tumors, as we have shown and include MTORC, unfolded protein response, TP53, IFN and interleukin regulation (Table 1, Table 2, Table 3, Table 4, Table 5, Table 6 and Table 7). The gene discussed is ERBB2; the disease is rheumatoid arthritis.