BDNF and diabetes mellitus: LXA4, along with BDNF (brain-derived neurotrophic factor), EPA, DHA, AA, and GLA (gamma-linolenic acid), has been proposed to protect pancreatic β cells from the cytotoxic action of various chemicals, such as alloxan (AL), streptozotocin (STZ), doxorubicin (DB), and benzo(a)pyrene (BP)-induced cytotoxicity and may prevent the development of diabetes mellitus [161].