Tauopathies, such as Alzheimer’s disease (AD), frontotemporal dementia with parkinsonism, and progressive supranuclear palsy, are an increasingly prevalent class of neurodegenerative diseases characterized, in part, by hyperphosphorylation and aggregation of the microtubule-associated binding protein tau [1,2]. The gene discussed is MAPT; the disease is neurodegenerative disease.