Moreover, polymorphism in telomere-related genes TERT, TERC, the oligonucleotide/oligosaccharide-binding fold containing one gene (OBFC1), and regulator of telomere elongation helicase 1 (RTEL1) are associated with LC development by shortening of telomeres, leading to genomic instability [23,56,112,113,114,115]. This evidence concerns the gene RTEL1 and laryngotracheoesophageal cleft.