CNNM4 and hepatocellular carcinoma: The chosen miRNA subset is comprised of twodownregulatory miRNAs (miR-10a-5p and miR-24-2-5p) and two upregulatorymiRNAs (miR-891b and miR-4262), all of which have shown differentialexpression in models of HCC compared to normal phenotypes.−, , , , ,  We posited that they might be relevant to the aberrant regulationof Mg2+ homeostasis observed in the disease.−,  Transfection of hepatocellular carcinoma HepG2 cells with miRNAmimics of the selected hits resulted in changes in CNNM4 protein expressionthat parallel those obtained in the miRFluR assay (Figures A and S3).