The selected upregulators,miR-891b and miR-4262, have also been linked to HCC; for example,miR-891b has been shown to increase metastasis of SK-Hep-1 cells. In cellular models and HCC tissue samples, miR-4262is upregulated compared to normal hepatic tissue and cell lines. Again, higher expression of this upregulatorymiRNA in HCC is consistent with a net upregulation of CNNM4 and apotential role in this liver pathology. Here, CNNM4 is linked to hepatocellular carcinoma.