CNNM4 and breast cancer: To assess the ability ofmiRNAs to affect CNNM4 expression more broadly across cell types,we also tested the selected miRNA mimics in the breast cancer cellline MCF7 (Figures C and S3), which shows robust endogenousexpression of CNNM4., Both miR-10a-5p and miR-24-2-5psignificantly reduced CNNM4 expression, while only miR-4262 significantlyupregulated CNNM4 in MCF7 cells.