CNNM4expression levels in colon cancer have been demonstrated to be inverselycorrelated to colon cancer malignancy, suggesting that control ofMg2+ homeostasis by CNNM4 is important for colon cancerprogression. Work from our and the Martinez-Chantargroup has also demonstrated that CNNM4 upregulation leads to chronicdepletion of intracellular Mg2+ in models of NASH and AILI,,, whereas silencing of the geneleads to restoration of cation levels and reversal of the diseasephenotype in animal models of both conditions. The gene discussed is CNNM4; the disease is colonic neoplasm.