It is predominantly expressedin the brain, intestine, and kidneys., Clinically,deleterious genetic mutations in CNNM4 result inJalili syndrome, characterized by cone-rod dystrophy and amelogenesisimperfecta., Upregulation of CNNM4 in livercells has been recently linked to acetaminophen-induced liver injury(AILI) and to the development of Non-AlcoholicSteatohepatitis (NASH), which contributesto the incidence of hepatocellular carcinoma (HCC). This evidence concerns the gene CNNM4 and Down syndrome.