CNNM4 and digestive system neoplasm: CNNM4expression levels in colon cancer have been demonstrated to be inverselycorrelated to colon cancer malignancy, suggesting that control ofMg2+ homeostasis by CNNM4 is important for colon cancerprogression. Work from our and the Martinez-Chantargroup has also demonstrated that CNNM4 upregulation leads to chronicdepletion of intracellular Mg2+ in models of NASH and AILI,,, whereas silencing of the geneleads to restoration of cation levels and reversal of the diseasephenotype in animal models of both conditions.