With regards to the latter, miR-10a has beenshown to be downregulated in HCC tissues as well as in multiple hepatomacell lines such as HepG2, HepG3, SMML7721, and SK-Hep-1, comparedto normal liver tissues and cells., This is consistentwith a net upregulation of CNNM4 in liver disease. This evidence concerns the gene CNNM4 and hepatocellular carcinoma.