Here, we reported seven individuals carrying heterozygous variants in PLCG1 (GenBank: NM_002660.3) who exhibit partially overlapping clinical features including hearing impairment (5/7), ocular pathology (4/7), cardiac defects (3/6), abnormal brain MRI findings (2/3), and immunological issues with diverse manifestations (5/7). The gene discussed is PLCG1; the disease is Hearing impairment.