Importantly, the tetrapeptide-based cleavable linker of Dato-DXd is cleaved by lysosomal enzymes differentially expressed in tumor cells, ensuring the ADC has stability while in systemic circulation, thus limiting systemic toxicity (18), in addition to allowing for a bystander effect against nearby TROP2-negative tumor cells within the tumor microenvironment. The gene discussed is TACSTD2; the disease is neoplasm.