Lumican isa small leucine rich repeat proteoglycan (SLRP) multifunctional KS‐proteoglycan. Leucine rich repeat domain‐9 (LRR9) is a peptide module (lumcorin) and a matrix metalloprotease (MMP) inhibitor (Zeltz et al. 2009; Pietraszek et al. 2014). LUM has anti‐angiogenic (Niewiarowska et al. 2011) and anti‐tumor properties (Zeltz et al. 2009; Coulson‐Thomas et al. 2013; Pietraszek et al. 2013). LUM regulates synthesis of small regularly spaced collagen fibrils in cornea essential for vision (Nikitovic et al. 2008; Kao and Liu 2002). Here, LUM is linked to neoplasm.