The main pathological hallmarks of AD include the two neuropathological markers: amyloid plaques, which consist of extracellular deposition of misfolded and aggregated amyloid‐β (Aβ) peptides, and neurofibrillary tangles, which are intraneuronal aggregates composed of the hyperphosphorylation of tau protein (p‐tau) (Knopman et al. 2021). Here, MAPT is linked to Alzheimer disease.