On the other hand, in AD, EVs have been shown to carry and disseminate misfolded proteins such as Aβ and tau, exacerbating neurodegeneration throughout the body (Chivet et al. 2012; Kalani et al. 2014; Tsilioni et al. 2014; Kanninen et al. 2016; Paschon et al. 2016; Thompson et al. 2016; Raghav et al. 2022). The gene discussed is MAPT; the disease is Alzheimer disease.