Since one of the main features of MPN pathogenesis is the presence of an inflammatory milieu,31 we also investigated whether the presence of inflammatory stimuli, like lipopolysaccharide (LPS) and interleukin‐1 β (IL‐1β) stimulation, could promote the proliferation of CRISPR‐edited JAK2V617F clones. Here, IL1B is linked to myeloproliferative neoplasm.