RETN and periodontitis: By attaching to receptors and triggering several intracellular signaling pathways [NF-κB, mitogen-activated protein kinase (MAPK), and AMP-activated protein kinase (AMPK)], especially through caspase recruitment domain-containing protein 1 (CAP1)+ classical monocytes, resistin may be responsible for this phenomenon, which makes periodontitis a precursor to T2DM (Lee et al., 2023).