In a cohort study involving 71 subjects, Alkan and Guzeldemir-Akcakanat (2021) found that by modifying the amounts of adipokines (IL-1β, TNF-α, leptin, resistin, and adiponectin) in the serum, saliva, and gingival crevicular fluid of obese female patients, different severity of periodontal disease affected general health. Here, LEP is linked to periodontal disorder.