Chitin oligosaccharides can increase SCFAs content, reduce serum LPS, improve blood lipid profiles and liver steatosis, decrease the levels of inflammatory factors such as IL-1β, IL-6, and TNF-α to alleviate inflammation, and promote mRNA expression of TJPs to enhance the integrity of the IMB (Zhen et al., 2022). This evidence concerns the gene IL1B and fatty liver disease.