Chitin oligosaccharides can increase SCFAs content, reduce serum LPS, improve blood lipid profiles and liver steatosis, decrease the levels of inflammatory factors such as IL-1β, IL-6, and TNF-α to alleviate inflammation, and promote mRNA expression of TJPs to enhance the integrity of the IMB (Zhen et al., 2022). The gene discussed is TNF; the disease is fatty liver disease.