CCR5 and HIV-1 infection: The authors of this study hypothesize that since CCR5+ T cells usually also express CXCR3, ITAC plays an important role to recruitment of these susceptible cells to HIV-1 infected regions or cells; this recruitment might then be able to “enhance the sequestration of T cells in infected lymphoid organs and spread of HIV-1 infection between cells” (Foley et al., 2005).