Many studies have reported that advanced age, high blood pressure, Hyperlipidemia, smoking, high sodium diet, high body mass index, lead exposure, non-optimal temperature and some biomarkers such as kidney injury molecule 1 (KIM-1) and tumor necrosis factor receptors 2(TNFR-2) were the risk factors of CKD (4, 19, 20). The gene discussed is HAVCR1; the disease is hypertensive disorder.