This high-quality article observed that with the occurrence of hyperglycemia, podocyte apoptosis in the kidney increased sharply by intervening the feeding environment of Ins2 (Akita) mice with type 1 diabetes and Lepr (db/db) (db/db) mice with obesity and type 2 diabetes. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.