SIRT1 and Hyperglycemia: This article observed the effects of hyperglycemia, the role of SIRT1 in podocyte protection, and the therapeutic potential of BF175 as a SIRT1 agonist, revealing the key role of SIRT1 in podocyte protection and the potential application of BF175 as a SIRT1 agonist in the treatment of DKD.