One study identified tumor size ≥2.5 cm, the number of lateral lymph node metastases (LLNMs) ≥3, level III metastases, and the B-type Raf kinase (BRAF) V600E mutation as independent predictors of level V metastasis (44). The gene discussed is BRAF; the disease is metastatic malignant neoplasm in the lymph nodes.