In contrast, patients with T2DM and T2DKD displayed numerous and more intense interactions, particularly between neutrophil sub-cell clusters (CAMK1D, CAMP, FOLR3, ISG15, MMP9, PI3) and MP sub-cell clusters (ClassicalMono, NonClassicalMono, cDCs, and pDCs) (Figures 6B–E). Here, ISG15 is linked to type 2 diabetes mellitus.