Given that neutrophils undergoing senescence and NET formation are typically cleared by MPs (31), the scLacNAc-seq results, which showed a significant increase in FOLR3 and PI3 subpopulations associated with aging and NET formation in patients with T2DM and T2DKD, prompted us to hypothesize enhanced neutrophil-MP interactions. This evidence concerns the gene PI3 and type 2 diabetes mellitus.