The interactions between MPs and neutrophils in T2DM and T2DKD patients were found to be predominantly mediated by CXCL8 and CXCR2 ligand-receptor pairs, with the strongest and most significant interactions observed between ClassicalMono MPs and FOLR3 and PI3 neutrophil sub-clusters (Supplementary Figure 6). This evidence concerns the gene CXCL8 and type 2 diabetes mellitus.