Having demonstrated the siRNA activity of the Cond-siRNA in NRVMs in the presence of PE-induced upregulation of Nppa, we next sought to characterize the effects of the Cond-siRNAs on CaN and its downstream signaling and the expression of other pathological cardiac hypertrophy markers under baseline (PBS) or PE treatment.30 This evidence concerns the gene NPPA and cardiac hypertrophy.