Several studies have identified amyloid-β (Aβ) and hyperphosphorylated tau (pTau) proteins as key contributors to AD pathology due to their accumulation in insoluble aggregates and soluble oligomeric forms, with the latter considered primarily responsible for early synaptic failure (Selkoe, 2002; Spires-Jones and Hyman, 2014), especially at hippocampal level (Henstridge et al., 2019). Here, MAPT is linked to Alzheimer disease.