Anaphylaxis, first described by Charles Richet and Paul Portier in 1902, is an acute, serious, systemic, and life-threatening IgE-mediated hypersensitivity reaction [1]. It typically manifests with a combination of urticaria, pruritus, angioedema involving the lips, tongue, or throat, respiratory distress in the form of wheezing, stridor, dyspnea, hypotension, syncope, abdominal pain, vomiting, and incontinence [2,3]. These symptoms are the result of a cascade of inflammatory mediators and cytokines released from mast cells and basophils following exposure to an allergen. The gene discussed is IGHE; the disease is anaphylaxis.