CTLA4 and hyperinsulinemic hypoglycemia, familial, 4: CTLA-4 haploinsufficiency with autoimmune sequelae, lipopolysaccharide-responsive and beige-like anchor protein deficiency with autoantibodies, Treg defects, autoimmune infiltration, and enteropathy are human genetic disorders associated with deficient CTLA-4 expression and function [10].