Objective: In this retrospective study conducted at Yulin Hospital, the First Affiliated Hospital of Xi’an Jiaotong University (Yulin, SN, CHN), we aimed to investigate the predictive role of CX3CL1 and D-dimer for mortality in hospitalized chronic obstructive pulmonary disease (COPD) patients with COVID-19. This evidence concerns the gene CX3CL1 and COVID-19.