IDH2 and neoplasm: These tumors are specifically characterized by MYB or MYBL1 alterations and a lack of mutations in IDH1, IDH2, TP53, ATRX, and H3 genes. Methylation studies using t-distributed stochastic neighbor embedding (t-SNE) analysis identified a single cluster, regardless of tumor site, neuroradiologic findings, or histopathologic features, indicating that this neoplasm is molecularly distinct despite overlapping clinicopathologic characteristics (Figure 1) [14].