IDH2 and central nervous system cancer: In contrast, diffuse low-grade glioma (MAPK pathway altered) shares morphologic features with other pediatric diffuse (non-IDH-mutant) low-grade gliomas and, therefore, displays minimal infiltration of the surrounding cortex, much less than adult-type IDH-mutated gliomas but more than pediatric circumscribed gliomas (such as pilocytic astrocytoma and pleomorphic xanthoastrocytoma) [42].