PIK3CA and CLOVES syndrome: Congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal anomalies (CLOVES) syndrome is a rare, sporadic overgrowth disorder caused by a post-zygotic mutation in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene [1].