MLANA and melanoma: Clinically, melanoma is classified into several subtypes, including superficial spreading, nodular, lentigo maligna, and ALM, with each variant demonstrating distinct anatomic predilections and growth patterns [2]. Diagnosis frequently relies on immunohistochemical staining, with markers such as S-100, SOX10, Melan-A (MART-1), and HMB-45 being essential for confirmation [1,3].