IL: interleukin; PTGS2/COX-2: prostaglandin-endoperoxide synthase 2; NLRC4: NOD-like receptor family CARD domain-containing protein 4; MEFV, Familial Mediterranean Fever; CFLAR: caspase 8 and FADD-like apoptosis regulator; CASP5: caspase 5; PCR: polymerase chain reaction. Here, CASP5 is linked to familial Mediterranean fever.