When comparing the specimens obtained at the initial visit and those taken one week later, interleukin (IL)-17A and IL-22 were expressed in the right eye, and IL-1β, prostaglandin-endoperoxide synthase 2 (PTGS2/COX-2), NOD-like receptor family CARD domain-containing protein 4 (NLRC4), Familial Mediterranean Fever (MEFV) gene, and caspase 5 (CASP5) decreased by more than six-fold. Changes in biomarkers associated with psoriasis pathology can be observed in ocular surface tests of patients with psoriasis-associated conjunctivitis. Here, CASP5 is linked to familial Mediterranean fever.