In the CNS infection patients, the ICU, LHS, HE, AAR, mNGS positivity rate, and the proportion of CSF with cloudy appearance, as well as CSF cell count and albumin levels, were all significantly higher than those in non-CNS infection patients; In contrast, the prognosis improvement rate and CSF chloride and glucose levels were lower (P<0.05) (Table 1). Here, ALB is linked to hereditary elliptocytosis.