This discovery, together with SAP research (Tripathi et al., 2019), clarifies that simultaneously targeting distinct cell death pathways—apoptosis, pyroptosis, and neutrophil extracellular trap (NET) formation—and their regulatory factors, such as PD-L1, GSDMD, and SAP, constitutes a synergistic therapeutic strategy for sepsis. The gene discussed is GSDMD; the disease is Sepsis.