The study found that broad-spectrum antibiotic treatment increases the susceptibility of mice to Mycobacterium tuberculosis, while Bacteroides fragilis can enhance anti-tuberculosis immunity by regulating lncRNA-CGB (which regulates IFN-γ expression through interaction with EZH2), revealing the role of the intestinal bacteria-related axis in tuberculosis immune protection and a new paradigm for treatment (Yang et al., 2022). Here, IFNG is linked to tuberculosis.