Activated matrix subtypes are characterized by elevated expression of macrophage-related molecular genes, including Integrin subunit alpha M, C-C motif chemokine ligand 13(CCL13)and CCL18, as well as tumor-promoting secretory protein genes such as secreted protein acidic and rich in cysteine, gelatinase B (MMP9), and stromal hemolysin 3 (MMP11) (13). This evidence concerns the gene CCL13 and neoplasm.