Solute carrier family 7 member 11 (SLC7A11/xCT), which is overexpressed in most cancer cells, imports extracellular cystine and reduces it in the cytoplasm to cysteine with the help of glucose-derived nicotinamide adenine dinucleotide phosphate (NADPH), which serves as a precursor for the synthesis of GSH, thus enabling antioxidant defense (11, 12). The gene discussed is SLC7A11; the disease is cancer.