However, although no significant differences in the expression of TIGIT and PD-1 were observed between the FLT3-ITD mutant and wild-type groups when analyzed in the overall T cell population in some samples (15), it is important to note that the immunosuppressive effects are primarily determined by the expression of immune checkpoint receptors on T cells that specifically recognize leukemia antigens (40). The gene discussed is PDCD1; the disease is leukemia.