Due to the limited evidence supporting a role for CCR1, CCR2, CCR3, CCR5, CCR6, CXCR1, CXCR2, CXCR5, and CX3CR1 in the pathogenesis or progression of MF and SS, their physiological functions will be briefly summarized. Here, CXCR2 is linked to synovial sarcoma.