CCR8 has emerged as a key skin-homing receptor expressed on neoplastic T cells in MF and SS, and its involvement appears especially relevant in advanced stages of disease: it has been demonstrated that CCR8 is upregulated on malignant CD4+ T cells in SS and tumor-stage MF, contributing to their epidermotropism and persistence in skin (43, 44). This evidence concerns the gene CCR8 and synovial sarcoma.