The roles of CCR1, CCR2, CCR3, CCR6, CXCR1, CXCR2, CXCR5, and CX3CR1 in CTCLs have been investigated, but findings indicate that these chemokine receptors play a minimal or no role in the pathogenesis of MF/SS. This evidence concerns the gene CX3CR1 and synovial sarcoma.