Studies have shown that melanocytes can significantly upregulate the expression of MHC class I molecules, chemokines such as CXCL9/10 under IFN-γ stimulation, further recruit CXCR3+ T cells to migrate to the skin, and strengthen the positive feedback of immune attack; this mechanism has been repeatedly confirmed in a variety of vitiligo models and ICI-related vitiligo (114). Here, IFNG is linked to vitiligo.