Radiotherapy induced tumor cell death releases DAMage-associated molecular patterns (DAMPs), which in turn promote the activation and killing of CD8+T cells (8)Radiation therapy can promote antigen (9)recognition, activate dendritic cells, and stimulate the expression of MHC-1 molecules, thereby improving the killing effect of CD8+T cells on tumors (Figure 1). The gene discussed is CD8A; the disease is neoplasm.