In a more recent attempt to improve CAR-T immunotherapy in pancreatic cancer, Zhang and coworkers incorporated short hairpin RNA (shRNA) sequences targeting HDAC11 into the NKG2D (Natural killer group 2 D receptor)-targeted CAR-T cells (they termed them sh-NKG2D-CAR) (189). This evidence concerns the gene KLRK1 and pancreatic neoplasm.