One remarkable example of immune cells which can change allegiances is the tumor associated macrophage which can take a proinflammatory and antitumoral M1-like phenotype or a myelosuppressive M2-like phenotype which prevents T lymphocyte mediated cytotoxicity by secreting PD-L1 and CTLA4-lingands and is associated with poor prognosis (169, 170). This evidence concerns the gene CTLA4 and neoplasm.